Relaxation and related 1H nmr studies on "asperlin." Configuration and conformation of the epoxypropyl side-chain

Abstract

Monoselective and biselective spin-lattice relaxation rates, together with nOe experiments, have been used to examine the configuration and conformation of the epoxypropyl side-chain of "asperlin" (1) in benzene solution. The data confirm earlier evidence that the oxirane ring is trans, and indicate that 1 is the 6R, 7S diastereomer. Moreover, it is shown that in the most probable conformation of the side-chain about the C-5, C-6 bond, H-5 and H-6 are anti.