Total synthesis of mycophenolic acid-Reference-Cited by-同舟云学术

Total synthesis of mycophenolic acid

Published:1997-06-01 Issue:6 Volume:75 Page:641-645
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

de la Cruz Ricardo A.,Talamás Francisco X.,Vázquez Alfredo,Muchowski Joseph M.

Abstract

A total synthesis of mycophenolic acid is reported. Diels–Alder reaction of [5-methoxy-3-(1-methoxypropenyl)-4,5-dihydrofuran-2-yloxy]-trimethylsilane with 3-benzenesulfinyl-5H-furan-2-one afforded the hexasubstituted nucleus. The side chain was constructed from the unveiled aldehyde. Keywords: mycophenolic acid, Diels–Alder reaction, pentasubstituted diene.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/v97-078

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