La S-adénosyl-L-homocystéine : 2. Anticonvulsivante

Abstract

S-Adenosyl-L-homocysteine (SAH) decreases the epileptiform discharges induced by hippocampic stimulation. SAH reduces the pentetrazol convulsions, does not modify picrotoxine convulsions, and increases strychnine toxicity. These effects are not linked to γ-aminobutyric acid metabolism perturbation or to the concentration of some amino acids known for their action in synaptic transmission.