13C N.M.R. STUDIES: VIII. 13C SPECTRA OF SOME SUBSTITUTED ANISOLES

Abstract

The 13C nuclear magnetic resonance spectra of a series of 40 substituted anisoles have been obtained to investigate the effects of substitution on the aromatic and methoxyl carbon shieldings. This work extends our studies on the variations of chemical shifts of carbon nuclei in side chains of aryl derivatives. The question of steric hindrance to conjugative interaction of a methoxyl group with an aromatic ring is considered on the basis of the present results. Evidence of a steric effect in compounds in which both ortho positions are substituted is presented.