Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2

Abstract

An accumulation of evidence implicates leptin, insulin, glucocorticoids, proopiomelanocortin (POMC), and neuropeptide Y (NPY) interactions as being integral to metabolic control associated with neuroendocrine-endocrine functioning. Dysfunction of neuroendocrine-endocrine interactions contributes to the metabolic disturbances of diabetes mellitus type 2 (DM-2). Since Zn has a direct impact on the healthy functioning of hormonal and neuropeptide balance, it is possible that altered Zn status and metabolism in DM-2 are involved in some of the metabolic dysfunctions of DM-2.Key words: zinc, insulin, leptin, neuropeptide Y, glucocorticoids, proopiomelanocortin (POMC), diabetes, obesity.