Author:
Sinha J. N.,Dhawan K. N.,Chandra O.,Gupta G. P.
Abstract
The present study was undertaken to investigate the role of acetylcholine in central vasomotor regulation in dogs. Both acetylcholine and carbachol produced a pressor response on intracerebroventricular (i.c.v.) administration. This response was completely blocked by pretreatment with i.c.v. atropine. Administration of hemicholinium into the lateral cerebral ventricle as well as its topical application to the floor of the fourth ventricle depressed the responsiveness of the medullary vasomotor center. Furthermore, choline, a precursor of acetylcholine, reversed the effects of hemicholinium. It is concluded that acetylcholine has an excitatory role in the medullary vasomotor center.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
36 articles.
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