Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons
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Published:1979-08-01
Issue:8
Volume:57
Page:917-920
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ISSN:0008-4212
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Container-title:Canadian Journal of Physiology and Pharmacology
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language:en
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Short-container-title:Can. J. Physiol. Pharmacol.
Author:
Phillis J. W.,Edstrom J. P.,Ellis S. W.,Kirkpatrick J. R.
Abstract
Intravenously administered theophylline (50–100 mg/kg) antagonized the depressant actions of adenosine and flurazepam on rat cerebral cortical neurons. When assessed in conjunction with recent reports that theophylline competes with diazepam for binding sites in brain tissue, this finding suggests that one action of the benzodiazepines may be exerted at a purinergic receptor associated with central neurons.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
54 articles.
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