Author:
Shah Ravindra M.,Donaldson David,Burdett David
Abstract
Pregnant hamsters were treated with different doses of oral and intravenous diazepam during the period of organogenesis. Teratogenic effects of diazepam were observed following oral treatment on days 8 and 10 and following intravenous treatment on day 11 of gestation. Types of malformations included cleft palate, exencephaly, limb anomalies, and hemorrhage. A dose–effect relationship was not observed. Comparison with reported literature seems to indicate that diazepam may be a mild teratogen in some species.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
15 articles.
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