Neuronal growth and target recognition: lessons from the leech

Abstract

The nervous system of the leech has been the subject of numerous studies since its "rediscovery" in the 1960s as a unique system for the study of the properties of glial cells. Subsequently, anatomical, physiological, and embryological studies of identified neurons have yielded a wealth of information about the differentiation of neuronal structure and function. In recent years, cellular approaches to the development of identified central and peripheral neurons have been complemented by molecular studies that promise to reveal the mechanisms by which neurons form their complex arbors and innervate specific targets.