Total Synthesis of (±)-Ishwarane, a Tetracyclic Sesquiterpenoid

Abstract

A total synthesis of (±)-ishwarane, a novel tetracyclic sesquiterpenoid possessing a tricyclo[3.2.1.02,7]octane system, is described. Completion of the synthesis of ishwarane firmly establishes the structure assigned to this sesquiterpenoid and provides corroboration of the structure assigned to the related sesquiterpenoid ishwarone. A total synthesis of (±)-isoishwarane, a transformation product of ishwarone, is also described.