Toxicité génétique du chlorure de méthylmercure (CH3HgCl) sur les mitochondries de Saccharomyces cerevisiae

Author:

Phipps J.,Miller D. R.

Abstract

Among the strains of the yeast Saccharomyces cerevisiae we investigated, the organic form of mercury:methylmercury (II) does not seem to induce any cytoplasmic mutant "petite colonie" rho. However, it induces a significant number of the erythromycin-resistant mutant Eryr. A dose response is shown. These effects are discussed in the view of the part that discrete DNA lesions could take in the explanation of the mechanism of toxicity of the organomercurial.

Publisher

Canadian Science Publishing

Subject

Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mercury toxicity in plants;The Botanical Review;2000-07

2. Genotoxicity of mercury compounds. A review;Mutation Research/Reviews in Genetic Toxicology;1994-02

3. Induction of the cytoplasmic ‘petite’ mutation by chemical and physical agents in Saccharomyces cerevisiae;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;1992-01

4. Interaction of methylmercury chloride with cellular energetics and related processes;Toxicology and Applied Pharmacology;1984-11

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