Affiliation:
1. Department of Community Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
2. National Institutes of Health, Bethesda, MD 20892-7517, USA.
Abstract
To evaluate how non-high-density-lipoprotein (non-HDL) is associated with impaired fasting glucose (IFG) and clustered metabolic risk (MR) factors among adolescents, we pooled 2764 adolescents, aged 12–19 years, from the National Health and Nutrition Examination Survey from 3 time periods (1999–2000, 2001–2002, and 2003–2004) who were free of diabetes and had fasted overnight for this analysis. IFG was defined as 100 ≤ glucose ≤ 125 mg·dL–1. Age- and sex-specific cut-offs were used for 4 MR factors: higher levels of triglycerides, waist circumference, blood pressure, and lower levels of HDL. Clustered MR was defined as having any 2 of the 4 factors. Overall, approximately 11% of adolescents had IFG. The mean level of non-HDL cholesterol was much higher in those with IFG than in those without IFG, with adjustment for certain confounding variables (121.4 vs. 110.1 mg·dL–1; p < 0.05). This difference could still be observed in adolescents with one or more clustered MR factors. However, there were no statistical differences in low-density-lipoprotein (LDL) level. Compared with those who were without IFG and not at high levels of non-HDL — after adjustment for age, sex, race, current smoking, and body mass index — the odds of having clustered MR factors were 1.08 (95% CI, 0.65–1.82) for those with IFG and low non-HDL cholesterol, 3.55 (2.29–5.48) for those without IFG but with high non-HDL cholesterol, and 10.10 (3.67–27.80) for those with both IFG and high non-HDL cholesterol. Moreover, those with IFG and at increased risk of obesity were more likely to have higher levels of non-HDL cholesterol (odds ratio (95% CI): 4.41 (2.28–8.50)), compared with those without IFG and not at increased risk of obesity. In summary, prediabetic adolescents with IFG and high levels of non-HDL cholesterol are more likely to have clustered MR factors. Thus, the levels of non-HDL cholesterol may be an important indicator in monitoring cardiovascular disease risk among adolescents with IFG.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism
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