Author:
Smith Clinton R.,Yates Keith
Abstract
Comparison of rate data for the acid-catalyzed hydrolysis of amides, and model compounds for O- and N-protonated amides, provides strong evidence that amides protonate predominantly on oxygen in dilute as well as in concentrated aqueous acids, contrary to a recent proposal that the protonation sites are different in the two media.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
45 articles.
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