Abstract
The equations for solute reabsorption in the proximal kidney tubule are derived, assuming Michaelis–Menten type kinetics and linear water reabsorption. Application of the equations to glucose shows that the transport system has a high affinity for glucose, being half saturated at less than 5 mgm. 100 ml. Most of the departure from ideal behavior of the human glucose saturation curve cannot be attributed to an unsaturated transport system. A dispersal of tubule absorptive capacity in a log-normal distribution can account for the curvature of the saturation curve.
Publisher
Canadian Science Publishing
Cited by
21 articles.
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