STUDY ON THE SYNTHESIS OF VALINE BY THE STRECKER METHOD

Abstract

A systematic investigation of the synthesis of dl-valine by the Strecker method, starting from isobutyraldehyde, has been made. The potassium-cyanide–ammonium-chloride procedure, as modified by us, has been found to be the most convenient for the large scale laboratory preparation of this amino acid, considering the over-all yield, the purity of the amino acid, and the time required, as well as the ease of preparation. A continuous ether extraction of the amino nitrile has been introduced. This accounts for the high yield and easy separation of the pure amino acid.