One-pot synthesis of propynoates and propynenitriles-Reference-Cited by-同舟云学术

One-pot synthesis of propynoates and propynenitriles

Published:2017-02 Issue:2 Volume:95 Page:144-148
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Shu Fan¹¹,Zheng Qingjuan¹¹,Dong Wanrong¹¹,Peng Zhihong¹¹,An Delie¹¹

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.

Abstract

An efficient transformation towards propynoates and propynenitriles is herein described. The practical methodology was conducted at low temperature (–78 or –60 °C) in a one-pot manner with the assistance of base rather than any transition metal catalysts. The base-induced protocol exhibits good functional group tolerance (up to 28 examples) and high efficiency (up to 92% yields) towards substituted acetylenes of great synthetic significance, which was also well demonstrated by the gram-scale reactions.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/cjc-2016-0181

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