An eco-friendly method for analysis of sulfonamides in water samples using a multi-pumping system

Author:

Catelani Tiago Augusto1,Castoldi Karine1,Tóth Ildikó Vargáné2,Santos João Luís Machado2,da Costa Lima José Luís Fontes2,Pezza Leonardo1,Pezza Helena Redigolo1

Affiliation:

1. Instituto de Química, Universidade Estadual Paulista “Julio de Mesquita Filho”, UNESP, R. Prof. Francisco Degni 55, P.O. Box 355, 14800-900, Araraquara, SP, Brazil.

2. REQUIMTE, Laboratório de Química Aplicada, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal.

Abstract

A new methodology for determination of sulfonamides (sulfaquinoxaline, sulfathiazole, and sulfadimethoxine) in water samples was developed by coupling an automated multi-pumping flow system (MPFS) with a liquid waveguide capillary cell (LWCC; pathlength, 100 cm) and a spectrophotometric detector. The method is based on the reaction between sulfonamides and p-dimethylaminocinnamaldehyde (p-DAC) in the presence of sodium dodecylsulfate (SDS) in dilute acid medium (hydrochloric acid), with measurement of the reaction products at 565 nm. Experimental design methodology was used to optimize the analytical conditions. The linear range obtained was 10.0–130.0 μg/L, and detection and quantification limits were 3.1 and 10.1 μg/L, respectively. The method was successfully applied to the analysis of sulfonamides in water samples. By coupling the MPFS with the LWCC, the sensitivity was enhanced, reagent consumption was low, and waste generation was minimized. The results obtained with the MPFS method were confirmed by LC–MS.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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