Ubiquinone levels of human liver in health and disease

Author:

Phillips W. E. J.,Hoppner K.,Murray T. K.,Campbell J. S.

Abstract

Total liver ubiquinone was not influenced by postmortem conditions when intact animals were exposed to room or refrigerator temperatures for periods of 24 h or a combined effect for 48 h. Liver ubiquinone declined progressively with duration of storage at −20 °C when liver tissue was stored but remained stable for 140 days when isolated nonsaponifiable material was stored. Recommendations are made for the routine handling of tissue samples for ubiquinone analysis. One hundred human livers were analyzed for ubiquinone. Age influenced liver ubiquinone content. Ubiquinone was low at birth and increased during the first year of life. No correlation was observed between ubiquinone concentration and primary cause of death, namely accidental, heart and coronary disease, cancer, respiratory diseases, and a miscellaneous group. Liver ubiquinone was not affected by the vitamin A status of humans. Extreme variations in ubiquinone concentration within any given age or disease group suggest that factors as yet not understood influence human liver ubiquinone levels.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

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