THE EFFECT OF GLUCAGON ON BLOOD SUGAR AND INORGANIC PHOSPHORUS LEVELS IN NORMOTHERMIC AND HYPOTHERMIC RATS

Author:

Crawford Anne L.,Henderson Margaret J.,Hawkins Rosemary D.,Haist R. E.

Abstract

Injection of glucagon into normothermic rats led to hyperglycaemia, and a significant fall in blood inorganic phosphorus levels. In hypothermic rats (25 °C) the injection of glucagon did not produce hyperglycaemia but the reduction in blood inorganic phosphorus levels was still obtained. Following the administration of glucagon, an increase in the excretion of inorganic phosphorus in the urine was observed in both normothermic and hypothermic rats. The fall in blood inorganic phosphorus level was considered to be due, in part at least, to the effect of glucagon in increasing the excretion of phosphorus in the urine.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The pathophysiology and clinical characteristics of severe hypophosphatemia;Archives of Internal Medicine;1977-02-01

2. Effect of Glucagon, Epinephrine, Cyclic 3',5'-AMP, N6-2'-0-Dibutyryl Cyclic 3',5'-AMP and Insulin upon the Phosphate Exchange of the Isolated Perfused Fed Rat Liver1;Endocrinology;1974-09

3. Glucagon: Chemistry and Action;Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products;1970

4. Effect of hypothermia on the secretion of immunoreactive insulin in response to glucose;Canadian Journal of Physiology and Pharmacology;1968-05-01

5. The effects of hypothermia and insulin on the distribution of glucose in some tissues of the rat;Canadian Journal of Physiology and Pharmacology;1968-05-01

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