Central Nervous System Interaction of Pyrazole and Ethanol in the Rat

Abstract

The degree of impairment of a motor performance test under the influence of alcohol (1.4–2.0 g/kg) was increased progressively by increasing doses of pyrazole (0–3.5 mmol/kg), which had no discernible effect of their own. Blood alcohol concentrations were not affected by pyrazole at the times of testing, indicating that the interaction was at the level of the central nervous system.