Affiliation:
1. Banting and Best Department of Medical Research, University of Toronto, Ontario
Abstract
The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radioautography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase, was purified 80-fold, and certain of its characteristics are reported. The possible role of the enzyme in the biological oxidation of the methyl group of methionine is discussed.
Publisher
Canadian Science Publishing
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献