Effect of 3-O-substituted analogues of D-glucose and D-allose on amino acid uptake by Penicillium sp.

Abstract

3-O-Methyl-D-glucose and 3-O-ethyl-D-allose cause an increase in growth rate of two dextranase-producing Penicillium species which is concomitant with an increase in amino acid uptake. In contrast, 3-O-ethyl-D-glucose and 3-O-methyl-D-allose have no effect on growth and inhibit uptake of L-glutamic acid. These results indicate that considerable specificity is involved in the response of Penicillium sp. to O-alkylated sugars and some O-alkylated sugars may reduce production time of extracellular enzymes.