Effect of infection with R23 on DNA and RNA synthesis in Escherichia coli

Abstract

Infection of Escherichia coli by R23 results in a marked inhibition of rRNA synthesis. Both 16 S and 23 S RNA are inhibited with maximal inhibition occurring at 30 min. Inhibition of 4 S RNA is not as profound. DNA synthesis is also inhibited after R23 infection although infected cells continue to divide for about one generation (45–60 min) after infection.