THIAZOLOISOQUINOLINES: II. THE SYNTHESIS OF THIAZOLO[5,4-c]ISOQUINOLINE

Abstract

Thiazolo[5,4-c]isoquinoline (I) has been synthesized by cyclization of 4-amino-3-thiocyano-isoquinoline (IX) to 2-aminothiazolo[5,4-c]isoquinoline (X), which was converted into I via the 2-chloro derivative XI. Some 2-substituted derivatives of I were obtained by displacement of the chlorine atom in XI. The attempted preparation of 3-chloro-4-nitroisoquinoline as an intermediate in the synthesis of I was unsuccessful. Nuclear magnetic resonance and ultraviolet spectra of I and its derivatives were investigated.