Author:
Tam Siu-Cheung,Blumenstein Jan,Wong J. Tze-Fei
Abstract
Exchange transfusions in dogs were performed with a solution of either dextran or a covalent complex between dextran and human hemoglobin. Dogs transfused with dextran alone died when their hematocrit was lowered to 6–10%. Dogs transfused with the dextran–hemoglobin complex, however, survived a reduction of their hematocrit to 2% or below. In the latter animals, the dextran–hemoglobin complex disappeared from the circulation with an average half-life of 2.4 days. Correcting for oxidation of the hemoglobin moiety to methemoglobin, the half-life of functional unoxidized dextran–hemoglobin in the circulation was 1.9 days. In compensation for the loss of dextran–hemoglobin, vigorous erythropoiesis was observed at a rate of close to 5% hematocrit per day over the first 2 days following the exchange transfusion. As a result, the total hemoglobin concentration in blood was maintained at 5–6% during this period, and the animals went on to complete recovery in room air without the need for further transfusion with dextran–hemoglobin.
Publisher
Canadian Science Publishing
Cited by
40 articles.
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