Permeability of Human Erythrocytes to Isonicotinic Acid Hydrazide and its Metabolites

Abstract

Intra- and extracellular concentrations of isonicotinic acid hydrazide equalized rapidly in suspensions of washed human or rabbit erythrocytes incubated with the drug in Tyrode solution at pH 7.4, 37 °C. Thus, contrary to an earlier report, erythrocytes are not impermeable to this compound. Of its known human metabolites, only the hydrazones with pyruvic and α-ketoglutaric acids were excluded from human erythrocytes.