Author:
Abelenda M.,Castro C.,Venero C.,Puerta M.
Abstract
It has been previously shown that responsiveness to noradrenaline is reduced in brown adipocytes isolated from estradiol-treated rats. The possibility that high plasma levels of progesterone could also alter adrenergic response was checked. The oxygen consumption of brown adipocytes isolated from control and progesterone-treated rats was monitored in basal conditions and in the presence of increasing concentrations of noradrenaline. In both situations, cells isolated from treated animals showed a lower respiratory rate than those from control animals. These results suggest that not only estradiol but also progesterone could modulate the adrenergic response of brown adipocytes. The study of α1- and β-adrenergic responses indicates that the β-response parallels the general reduction in oxygen consumption, although the α 1-response seems to be more deeply depressed. Estimation of cell number in brown fat depots indicates some hyperplasia induced by progesterone; this increase in cell number could counterbalance partially but not totally the decreased cellular oxygen consumption at the organ level.Key words: brown adipocytes, progesterone, noradrenaline, oxygen consumption, sympathetic nervous system.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
11 articles.
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