Abstract
Free virus (T1) particles are not taken up by guinea pig polymorphonuclear leucocytes, but they are destroyed or inactivated by heated leucocytes. When infected Escherichia coli is added to leucocytes an increase in the number of phage particles takes place. This increase is abolished if the leucocytes are previously exposed to phage-resistant E. coli but not if they are previously exposed to heat- or formalin-inactivated E. coli. The results seem to indicate that the leucocyte suspension acts as a source of nutrients necessary for phage reproduction. Whether phage synthesis by the infected bacteria takes place inside or outside the leucocytes is not entirely clear. However, the experiments suggest that phagocytosis of E. coli infected with T1occurs.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology