THE EFFECT OF INTRAVENOUSLY INJECTED CITRATE ON THE SERUM IONIZED CALCIUM IN THE RABBIT

Abstract

The effect of intravenously injected citrate solution, in various amounts and at different rates of administration, on the calcium ion concentration of the plasma was studied in the rabbit. The concentration of calcium ions was measured by means of the frog heart preparation. The rabbit is capable of rapidly clearing and disposing of large amounts of citrate. No effect on the calcium ion concentration of the blood could be demonstrated except when a concentrated solution of citrate was injected sufficiently rapidly to produce convulsions. Even under these conditions the calcium ion concentration in the blood was rapidly restored and usually a complete recovery was made within five minutes. Citrate is readily utilizable in the body.