Author:
Stewart Ross,Linden R. Van der
Abstract
A series of five trifluoroacetophenones and five phenyl trifluoromethyl carbinols have been synthesized and their ionization constants in water measured. They are the unsubstituted, p-methoxy, p-methyl, m-bromo, and m-nitro compounds. The ketones exist as hydrates in aqueous solution and each is about two pK units stronger than the corresponding alcohol. The acidities of both series are correlated by the Hammett relation with ρ values of 1.11 and 1.01 for the ketone hydrates and alcohols respectively. The acid strengths vary from a pKa of 9.18 for m-nitro-α,α,α-trifluoroacetophenone to 12.24 for p-methoxyphenyl trifluoromethyl carbinol.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
120 articles.
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