AMINO ACIDS AND PEPTIDES: II. SYNTHESIS OF ε-N-METHYL-L-LYSINE AND RELATED COMPOUNDS

Abstract

ε-N-Methyl-L-lysine, ε-N-ethyl-L-lysine, and δ-N-methyl-L-ornithine have been synthesized by alkylation of the α-N-benzoyl-ω-N-p-toluenesulphonylamino acid. ε-N-Methyl-L-lysine was also prepared by the formaldehyde – formic acid methylation of α-N-carbobenzoxy-ε-N-benzyl-L-lysine, obtained by borohydride treatment of α-N-carbobenzoxy-L-lysine in the presence of benzaldehyde. ε-N, ε-N-Dimethyl-L-lysine, ε-N-benzyl-L-lysine, and ε-N-methyl-L-lysine ethyl ester were also prepared.