Antineoplastic agents. 193. Isolation and structure of the cyclic peptide hymenistatin 1

Abstract

The Western Pacific Ocean sponge Hymeniacidon sp. was found to contain a cyclo-octapeptide designated hymenistatin 1 (1) active against the P388 leukemia cell line (ED50 3.5 μg/mL). Structural determination was accomplished utilizing high field NMR (400 MHz) and mass spectral techniques (FAB MS/MS) followed by chiral gas chromatographic analysis to establish the absolute configuration (all S-amino acids). Keywords: cytostatic, Hymeniacidon, hymenistatin, cyclo-octapeptide, P388 leukemia.