Affiliation:
1. Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Canada
Abstract
Further studies have been carried out to assess the reliability of the human bio-assay technique using the excretion of riboflavin to estimate the availability of sugar-coated tablets. Using eight individuals, it has been shown that for 1, 3, and 5 mgm. amounts of riboflavin the excretion is the same whether these amounts are taken as a single dose or in 10 small doses totalling the same amount. For doses of riboflavin of 1, 3, 5, 7.5, and 10 mgm. a linear relationship was found to exist between the amount ingested and excreted. The equation for this dose response line was found to be y = 0.580x − 0.610. The intercept − 0.610 was significantly different from zero, indicating that the line did not pass through the origin. The results furnish further evidence of the validity of the urinary excretion of riboflavin for determining the physiological availability of coated tablets.
Publisher
Canadian Science Publishing
Cited by
3 articles.
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1. Der Einfluß der Formgebung auf die Wirkung eines Arzneimittels;Fortschritte der Arzneimittelforschung / Progress in Drug Research / Progrès des recherches pharmaceutiques;1966
2. Multiple Dose Excretion Kinetics;Journal of Pharmaceutical Sciences;1963-03
3. The Relation between in Vitro Disintegration Time of Sugar-Coated Tablets and Physiological Availability of Sodium P-Aminosalicylate;Journal of the American Pharmaceutical Association (Scientific ed.);1956-06