Open science precision medicine in Canada: Points to consider

Author:

Granados Moreno Palmira1,Ali-Khan Sarah E.2,Capps Benjamin3,Caulfield Timothy4,Chalaud Damien5,Edwards Aled56,Gold E. Richard2,Rahimzadeh Vasiliki1,Thorogood Adrian1,Auld Daniel7,Bertier Gabrielle1,Breden Felix8,Caron Roxanne1,César Priscilla M.D.G.2,Cook-Deegan Robert9,Doerr Megan10,Duncan Ross11,Issa Amalia M.1121314,Reichman Jerome15,Simard Jacques16,So Derek1,Vanamala Sandeep5,Joly Yann1

Affiliation:

1. Centre of Genomics and Policy, Department of Human Genetics, McGill University, Montréal, QC H3A 0G1, Canada

2. Centre for Intellectual Property and Policy, Faculty of Law, McGill University, Montreal, QC H3A 1W9, Canada

3. Department of Bioethics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, Canada

4. Health Law Institute, Faculty of Law and School of Public Health, University of Alberta, Edmonton, AB T6G 2H5, Canada

5. Montreal Neurological Institute and Hospital, McGill University, Montreal, QC H3A 2B4, Canada

6. Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L6, Canada

7. McGill University and Genome Quebec Innovation Centre, Montreal, QC H3A 0G1, Canada

8. Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

9. School for the Future of Innovation in Society, Barrett & O’Connor Washington Center, Arizona State University, Washington, DC 20006, USA

10. Sage Bionetworks, Seattle, WA 98109, USA

11. Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada

12. Department of Family Medicine, McGill University, Montreal, QC H3S 1Z1, Canada

13. Personalized Medicine & Targeted Therapeutics, Philadelphia, PA 19803, USA

14. Health Policy & Pharmaceutical Sciences, University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA

15. School of Law, Duke University, Durham, NC 27708, USA

16. Genomics Center, Centre Hospitalier Universitaire de Quebec-Laval University, Quebec City, QC G1V 4G2, Canada

Abstract

Open science can significantly influence the development and translational process of precision medicine in Canada. Precision medicine presents a unique opportunity to improve disease prevention and healthcare, as well as to reduce health-related expenditures. However, the development of precision medicine also brings about economic challenges, such as costly development, high failure rates, and reduced market size in comparison with the traditional blockbuster drug development model. Open science, characterized by principles of open data sharing, fast dissemination of knowledge, cumulative research, and cooperation, presents a unique opportunity to address these economic challenges while also promoting the public good. The Centre of Genomics and Policy at McGill University organized a stakeholders’ workshop in Montreal in March 2018. The workshop entitled “Could Open be the Yellow Brick Road to Precision Medicine?” provided a forum for stakeholders to share experiences and identify common objectives, challenges, and needs to be addressed to promote open science initiatives in precision medicine. The rich presentations and exchanges that took place during the meeting resulted in this consensus paper containing key considerations for open science precision medicine in Canada. Stakeholders would benefit from addressing these considerations as to promote a more coherent and dynamic open science ecosystem for precision medicine.

Publisher

Canadian Science Publishing

Subject

Multidisciplinary

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