[Nphe1]nociceptin(1–13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat

Abstract

The purpose of this study was to investigate the effects of [Nphe1]nociceptin(1–13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe1]nociceptin(1–13)-NH2 (1.5–12 nmol/kg and 5-120 nmol/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol/kg, respectively) on MAP and HR. Furthermore, [Nphe1]nociceptin(1–13)-NH2 (5–120 nmol/kg) could reverse nociceptin (30 nmol/kg)-induced decrease of HVBR. However, [Nphe1]nociceptin(1–13)-NH2 had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe1]nociceptin(1–13)-NH2 acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.Key words: nociceptin, [Nphe1]nociceptin(1–13)-NH2, morphine, mean arterial pressure, heart rate, hindquarters vascular bed resistance.