Antibiotic Toxicity, Efficacy, and Teratogenicity in Adult Spring Chinook Salmon (Oncorhynchus tshawytscha)

Abstract

Antibiotics were tested for toxicity and efficacy in adult spring chinook salmon (Oncorhynchus tshawytscha) infected with bacterial kidney disease and furunculosis. The complex of penicillin G procaine, dihydrostreptomycin sulfate, and oxytetracycline-HCl was not toxic and it effectively controlled both diseases, producing a three-fold increase in adult survival and production of viable eggs.Mandible and fin teratogenesis occurred in progeny of adults treated with the above antibiotic complex, but could be reduced by providing a 32 day interim between injection and spawning.