The mineralocorticoid activity of 18-hydroxy-11-deoxycorticosterone, 11-deoxycorticosterone, and aldosterone in the adrenalectomized dog
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Published:1979-12-01
Issue:12
Volume:57
Page:1407-1411
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ISSN:0008-4212
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Container-title:Canadian Journal of Physiology and Pharmacology
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language:en
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Short-container-title:Can. J. Physiol. Pharmacol.
Author:
Constantopoulos George,Kusumoto Miyako,Gutkowska Jolanta,Genest Jacques
Abstract
The mineralocorticoid activity of 18-hydroxy-deoxycorticosterone (18-OH-DOC) was compared with that of deoxycorticosterone (DOC) and aldosterone in adrenalectomized adult female dogs. With respect to sodium retention, 18-OH-DOC was approximately five times less potent than DOC and 78 times less potent than aldosterone. With regard to the effect on potassium excretion 18-OH-DOC was 11 times less active than DOC and 615 times less than aldosterone.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
2 articles.
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