The effect of mebendazole on the development of Hymenolepis diminuta in Tribolium confusum

Abstract

Tribolium confusum parasitized by Hymenolepis diminuta were allowed to feed on mixtures composed of 0.005 to 20 g of mebendazole (Telmin: methyl-5-benzoyl benzimidazole-2-carbamate) in 10 g of flour from day 1 (24 h) to day 9 post infection. Retarded cysticercoid development, lowered incidence of infection, and reductions in the number of cysticercoids recovered per beetle were produced by drug levels of 0.1, 1.0, and 10 g respectively. None of the drug concentrations tested produced 100% mortality, and developing cysticercoids varied considerably in their tolerance of mebendazole.