Author:
Firnau Gunter,Chirakal Raman,Sood Sudesh,Garnett Stephen
Abstract
L-3-Methoxy-4-hydroxyphenylalanine was fluorinated directly with XeF2 in CH2Cl2 at −60 °C invacuo. After hydrolysis with 48% aqueous HBr, L-6-fluorodopa was obtained. The yield, based on XeF2, was 25%. This reaction might be applied when chiral biomolecules are to be tagged with fluorine-18.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
44 articles.
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