Author:
Doyle Terrence William,Conway Terry Thomas,Lim Gary,Luh Bing-Yu
Abstract
Treatment of the acid 3 with triethylamine in refluxing tert-butyl alcohol gave the decarboxylated product 4 which was isomerized to the desired Δ3 isomer 5 using DBN. Reduction of the azido functions in 4 and 5 followed by coupling to phenoxyacetic acid and debenzylation gave the acids 11 and 8, respectively. Attempts to prepare dienic cephalosporins failed. The halogenation of 4 and 5 was studied and is discussed.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
15 articles.
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