Characterization of 2,3,6,7,10,11-hexahydroxytriphenylene and its effects on cell viability in human cancer cell lines-Reference-Cited by-同舟云学术

Characterization of 2,3,6,7,10,11-hexahydroxytriphenylene and its effects on cell viability in human cancer cell lines

Published:2016-04 Issue:2 Volume:94 Page:205-211
ISSN:0829-8211
Container-title:Biochemistry and Cell Biology
language:en
Short-container-title:Biochem. Cell Biol.

Author:

Naidek Karine P.¹,Zuconelli Cristiane R.²,Cruz Otavio M.²,Ribeiro Ronny¹,Winnischofer Sheila M.B.²,Winnischofer Herbert¹

Affiliation:

1. Universidade Federal do Paraná, Dep. Química, C.P. 19081, 81531-980, Curitiba, Paraná, Brazil.

2. Universidade Federal do Paraná, Dep. Bioquímica e Biologia Molecular, C.P. 19046, 81531-980, Curitiba, Paraná, Brazil.

Abstract

We synthesized 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), characterized it by electrochemistry, spectroelectrochemistry, and electron paramagnetic resonance techniques, and evaluated its cytotoxicity to human cancer cell lines. The results revealed that HHTP has accessible higher-oxidation states, especially the tris-semiquinone monoradical. This species is stable and is formed after being stored for months. HHTP exhibited cytotoxic effects on 5 human cancer cell lines, including glioma and lung cancer cells. The cytotoxic effect was evaluated based on the decrease in cell viability, increases in the percentage of cells with fragmented DNA, and elevated numbers of annexin V–PI-positive cells after HHTP treatment.

Publisher

Canadian Science Publishing

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/bcb-2015-0093

Reference37 articles.

1. Structural investigation of a hydrogen bond order–disorder transition in a polar one-dimensional confined ice

2. Regulated Externalization of Phosphatidylserine at the Cell Surface

3. A new redox-tunable near-IR dye based on a trinuclear ruthenium(II) complex of hexahydroxytriphenylene

4. Polynuclear osmium–dioxolene complexes: comparison of electrochemical and spectroelectrochemical properties with those of their ruthenium analogues

5. Triphenylene hexa-n-alkylcyclohexanoates: a new series of disc-like liquid crystals

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