Author:
Coldwell B. B.,Paul C. J.,Thomas B. H.
Abstract
The effects of an acute dose of ethanol on the metabolism of 14C-phenobarbital was studied in the rat. The ethanol-treated rats had higher blood and tissue levels of radioactivity than control animals for 10–12 h following oral administration of the drugs. No redistribution of radioactivity between blood and tissues was observed. Only unchanged phenobarbital was found in the brain, and only traces of phenobarbital metabolites were detected in the blood and liver. Ethanol inhibited the excretion of radioactivity during the first 12 h after dosing. This was due to reduced excretion of p-hydroxyphenobarbital. It is concluded that ethanol inhibits the hydroxylation of phenobarbital in the rat.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
11 articles.
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