Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia-Reference-Cited by-同舟云学术

Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia

Published:2021-10 Issue:10 Volume:99 Page:1112-1113
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Badran Mohammad¹,Abuyassin Bisher²,Ayas Najib³⁴⁵,Sin Don D.⁶,Laher Ismail⁷

Affiliation:

1. Department of Child Health and the Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA.

2. Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

3. Divisions of Critical Care and Respiratory Medicine, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

4. Sleep Disorders Program, UBC Hospital, Vancouver, BC, Canada.

5. Division of Critical Care Medicine, Providence Health Care, Vancouver, BC, Canada.

6. The University of British Columbia Center for Heart Lung Innovation (HLI), St Paul’s Hospital, and Division of Respiratory Medicine, The University of British Columbia, Vancouver, BC, Canada.

7. Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Abstract

Obstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA have increased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicate that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

https://cdnsciencepub.com/doi/pdf/10.1139/cjpp-2021-0143

Reference15 articles.

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5. Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity

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