Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus-Reference-Cited by-同舟云学术

Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus

Published:2023-02-01 Issue:2 Volume:101 Page:74-79
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Fayaz Farshid¹,Zarban Asghar²,Aschner Michael³,Aramjoo Hamed¹,Roshanravan Babak¹,Foadodini Mohsen⁴,Abderam Amir¹,Samarghandian Saeed⁵,Farkhondeh Tahereh⁶

Affiliation:

1. Student Research Committee, Birjand University of Medical Sciences, Birjand, 9717853577, Iran

2. Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, 9717853577, Iran

3. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209, 1300 Morris Park Avenue, Bronx, NY 10461, USA

4. Department of Physiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, 9717853577, Iran

5. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, 9318614139, Iran

6. Department of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, 9717853577, Iran

Abstract

This study investigated the effect of buprenorphine (BUP) on the livers of pups exposed to this drug during the fetal stage. BUP decreased the activities of serum liver enzymes in exposed animals versus the controls. BUP (0.5 mg/kg) decreased malondialdehyde levels and increased the glutathione levels in the liver of animals versus other groups. The superoxide dismutase activity was elevated in the BUP 0.5 mg/kg group versus the control group. BUP (1 mg/kg) induced histopathological changes in the livers of pups. In conclusion, BUP may induce hepatotoxicity in pups exposed to this drug during the fetal stage.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

https://cdnsciencepub.com/doi/pdf/10.1139/cjpp-2022-0113

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