Basic mechanisms of secretion: sorting into the regulated secretory pathway

Abstract

Targeting proteins to their correct cellular location is crucial for their biological function. In neuroendocrine cells, proteins can be secreted by either the constitutive or the regulated secretory pathways but the mechanism(s) whereby proteins are sorted into either pathway is unclear. In this review we discuss the possibility that sorting is either an active process occurring at the level of the trans-Golgi network, or that sorting occurs passively in the immature granules. The possible involvement of protein-lipid interactions in the sorting process is also raised.Key words: lipid rafts, regulated secretory pathway, secretion, sorting receptors, sorting signals, trans-Golgi network.