Author:
Cole Richard J.,Kirksey Jerry W.,Wells John M.
Abstract
A new tremorgenic metabolite was found in the chloroform extracts of cultures of Penicillium paxilli. Purified tremorgen had a molecular formula of C27H33NO4 and data supported the presence of an indole moiety. Administration of the tremorgen orally to 1-day-old cockerels and intraperitoneally to mice caused sustained tremors that persisted for about 24 h. The tremorgen also caused mice to overreact to sound stimuli.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
81 articles.
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