Diazepam potentiation of purinergie depression of central neurons

Abstract

Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5′-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.