The Effect of Endurance Training on Phosphoinositide Metabolism of Extensor Digitorum Longus in Rats

Author:

Oueslati Habib,Gardiner Phillip

Abstract

We tested the hypothesis that endurance training results in changes in inositol triphosphate (InsP3) production from membrane phosphoinositides in trained muscles during contractile activity, which might have implications for fatigue involving calcium-release mechanisms. The extensor digitorum longus (EDL) muscles of endurance-trained rats were measured for membrane phosphoinositides, fatigability, and the production of inositol phosphates resulting from a 10-s tetanic contraction in vitro. In the latter, training resulted in a 22% increase in the production of inositol phosphates, in spite of lower phosphoinositides per muscle. In a separate group of animals, pretreatment of EDL in vitro for 15 min with 20 mM lithium resulted in a gradual decrease in tetanic forces at 100 Hz and increased fatigability. These results show for the first time that this metabolic system adapts to increased use and may contribute to the associated increased fatigue resistance, through its modulation of calcium release by sarcoplasmic reticulum. Key words: fatigue, exercise training, inositol phosphates, second messenger

Publisher

Canadian Science Publishing

Subject

Orthopedics and Sports Medicine,Physiology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Efficacy and Safety of “URSA Complex” in Subjects with Physical Fatigue;Chinese Medical Journal;2016-01-20

2. Skeletal myofiber VEGF is essential for the exercise training response in adult mice;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;2014-04-15

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