THE GENETICS OF DIABETES MELLITUS IN MAN

Author:

Simpson Nancy E.

Abstract

The genetics of diabetes mellitus in man has been reviewed. The evidence for genetic heterogeneity on clinical, biochemical and HLA (histocompatibility leukocyte antigens) data is presented. An attempt is made to interpret the meaning of the associations of the disease and certain HLA antigens and the complement factor, properdin in populations and in families. The population data can be best explained by the linkage disequilibrium hypothesis requiring tight linkage between the DS (diabetes susceptibility) locus and those in the MHC (major histocompatibility complex). Linkage between the DS locus and MHC from family data is estimated to be about 14%, which is not likely tight enough to be compatible with the population data; and a one locus or one allele hypothesis and genetic heterogeneity is postulated as the best explanation of the incompatibility between population and family data. It is still impossible to precisely define the exact genetic hypothesis for diabetes in man.

Publisher

Canadian Science Publishing

Subject

Cell Biology,Plant Science,Genetics

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Genetic heterogeneity for the development of audiogenic seizures in mice;Brain Research;1983-07

2. Genetic analysis of the BB/W diabetic rat;Canadian Journal of Genetics and Cytology;1983-02-01

3. TheHLAB*18,BF*F1 in haplotype in type 1 diabetes;American Journal of Medical Genetics;1982-03

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