The Protective Effect of Vitamin E Against Genotoxicity of Lead Acetate Intraperitoneal Administration in Male Rat

Author:

AITHAMADOUCHE Nadia,SADI Nesrine,KHAROUBI Omar,SLIMANI Miloud,AOUES Abdelkader

Abstract

Lead is industrial pollutant that may have toxic effects on the male. The aim of this study was to further investigate the protective effects of vitamin E on lead acetate (Pb) induced reproductive toxicities and genotoxicity effects in male rat. Sexually mature male Wistar rats (weighing 120-160 g) were given Pb (20 mg/Kg) and vitamin E (600 mg/kg/rat) orally for 20 days. The sperm counts, sperm motility, sperm morphology, chromosomal aberrations, FSH, LH and testosterone levels, and histopathological changes in the testes of these rats, were investigated at the end of 20 days. Result revealed a statistically significant (p

Publisher

University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca

Subject

Horticulture,Plant Science,Agricultural and Biological Sciences (miscellaneous),Agronomy and Crop Science,Biochemistry, Genetics and Molecular Biology (miscellaneous),Medicine (miscellaneous),Forestry

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